资源类型

期刊论文 82

会议视频 1

年份

2023 3

2022 6

2021 10

2020 13

2019 7

2018 5

2017 3

2016 6

2015 4

2014 3

2013 3

2012 4

2011 1

2010 4

2009 3

2008 2

2007 5

展开 ︾

关键词

COVID-19 2

SARS-CoV-2 2

中药 2

人工智能 2

代谢组学 2

多囊卵巢综合征 2

有效性 2

H7N9 1

N 1

N-二乙基乙醇胺 1

REC114 1

ZNF438 1

丁酸 1

三维守恒 1

不孕症 1

严重急性呼吸综合征冠状病毒2 1

中医方证代谢组学 1

中国 1

中国队列 1

展开 ︾

检索范围：

排序： 展示方式：

Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

《医学前沿（英文）》 2021年 第15卷 第4期   页码 585-593 doi: 10.1007/s11684-020-0817-2

摘要： Stevens--Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe diseases. This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China. Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included. Results showed that the severity-of-illness score for TEN (SCORTEN) had a good discrimination (area under the receiver operating characteristic curve (AUC), 0.78), and it was superior to auxiliary score (AS) and ABCD-10, which indicates age, bicarbonate level, cancer, dialysis, and 10% involved body surface area (AUC, 0.69 and 0.68, respectively). The calibration of SCORTEN (Hosmer–Lemeshow goodness-of-fit test, = 0.69) was also better than that of AS ( = 0.25) and ABCD-10 ( = 0.55). SCORTEN and ABCD-10 were similar (Brier score (BS), 0.04 and 0.04) in terms of accuracy of predictions. In addition, the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality. Refined models were formed using the variables and this imaging appearance. The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN (0.74 vs. 0.78, = 0.23; 0.74 vs. 0.78, = 0.30, respectively). Therefore, SCORTEN showed good discrimination performance, calibration, and accuracy, and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available.

关键词： Stevens–Johnson syndrome     toxic epidermal necrolysis     auxiliary score     ABCD-10     pulmonary consolidation    

HTML PDF 收藏

Ballistic behavior of plain and reinforced concrete slabs under high velocity impact

Chahmi OUCIF, Luthfi Muhammad MAULUDIN, Farid Abed

《结构与土木工程前沿（英文）》 2020年 第14卷 第2期   页码 299-310 doi: 10.1007/s11709-019-0588-5

摘要： This work presents a numerical simulation of ballistic penetration and high velocity impact behavior of plain and reinforced concrete slabs. In this paper, we focus on the comparison of the performance of the plain and reinforced concrete slabs of unconfined compressive strength 41 MPa under ballistic impact. The concrete slab has dimensions of 675 mm × 675 mm × 200 mm, and is meshed with 8-node hexahedron solid elements in the impact and outer zones. The ogive-nosed projectile is considered as rigid element that has a mass of 0.386 kg and a length of 152 mm. The applied velocities vary between 540 and 731 m/s. 6 mm of steel reinforcement bars were used in the reinforced concrete slabs. The constitutive material modeling of the concrete and steel reinforcement bars was performed using the Johnson-Holmquist-2 damage and the Johnson-Cook plasticity material models, respectively. The analysis was conducted using the commercial finite element package Abaqus/Explicit. Damage diameters and residual velocities obtained by the numerical model were compared with the experimental results and effect of steel reinforcement and projectile diameter were studies. The validation showed good agreement between the numerical and experimental results. The added steel reinforcements to the concrete samples were found efficient in terms of ballistic resistance comparing to the plain concrete sample.

关键词： Johnson-Holmquist-2     Johnson-Cook     reinforced concrete     damage     impact loads    

HTML PDF 收藏

Imaging studies of in-cylinder HCCI combustion

Pawel LUSZCZ, Hongming XU, Mirek WYZSNSKI, Xiao MA, Rob STEVENS, Athanasios TSOLAKIS

《能源前沿（英文）》 2011年 第5卷 第3期   页码 313-321 doi: 10.1007/s11708-011-0154-x

摘要： An optically accessed, single cylinder engine operated in homogenous charge compression ignition (HCCI) mode with negative valve overlap (NVO) strategy was used to perform combustion processes diagnostics under premixed conditions corresponding to the low load regime of the HCCI operational envelope. The aforementioned processes analysis was conducted utilizing synchronized simultaneous combustion event crank-angle resolved images, acquired through piston crown window with in-cylinder pressure recording. This investigation was carried out for one-step ignition fuel—standard gasoline, fuel proceeding single-stage ignition process under conditions studied. The initial combustion stage is characterized by a maximum local reaction spreading velocity in the range of 40–55 m/s. The later combustion stage reveals values as high as 140 m/s in case of stoichiometric combustion. The mixture as well as combustion stages effects are pronounced in these observed analytical results.

关键词： high speed imaging     combustion     homogenous charge compression ignition (HCCI)     reaction spreading velocity    

HTML PDF 收藏

Precipitation study of CO

Stevens, Guoping Hu, Wenshou Sun, Kathryn A. Mumford

《化学科学与工程前沿（英文）》 2020年 第14卷 第3期   页码 415-424 doi: 10.1007/s11705-019-1882-4

摘要： Focused beam reflectance measurement (FBRM) and C nuclear magnetic resonance ( C NMR) analysis were used to study the precipitation process of CO -loaded potassium glycinate (KGLY) solutions at different CO loadings, during the addition of ethanol as an antisolvent at a rate of 10 mL·min . The volume ratio of ethanol added to the KGLY solution (3.0 mol·L , 340 mL) ranged from 0 to 3.0. Three solid-liquid-liquid phases were formed during the precipitation process. The FBRM results showed that the number of particles formed increased with CO loading and ethanol addition for CO -unsaturated KGLY solutions, whilst for CO -saturated KGLY solution it first increased then decreased to a stable value with ethanol addition. C NMR spectroscopic analysis showed that the crystals precipitated from the CO -unsaturated KGLY solutions consisted of glycine only, and the quantity crystallised increased with CO loading and ethanol addition. However, a complex mixture containing glycine, carbamate and potassium bicarbonate was precipitated from CO -saturated KGLY solution with the maximum precipitation percentages of 94.3%, 31.4% and 89.6%, respectively, at the ethanol volume fractions of 1.6, 2.5 and 2.3.

关键词： crystallization     precipitation     glycinate     FBRM     13C NMR    

HTML PDF 收藏

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

《医学前沿（英文）》 2022年 第16卷 第4期   页码 651-658 doi: 10.1007/s11684-021-0859-0

摘要： To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifested primarily as throat discomfort, we conducted a multicentric and retrospective study in the cardiology and otorhinolaryngology departments. Records of patients with primary complaint of throat discomfort, absence of chest pain at onset, and an ultimate diagnosis of acute coronary syndrome, as well as patients with pharyngitis (as controls) were collected from May 2015 to April 2016. The patients’ main manifestations were compared. Logistic regression results showed that chest tightness, dyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndrome, with odds ratios of 8.3 (95% CI 2.2−31.5), 10.9 (95% CI 1.8−66.9), 25.4 (95% CI 3.6−179.9), and 81.2 (95% CI 13.0−506.7). A total of 25 (56.82%) out of 44 acute coronary syndrome patients, who were first admitted to the otorhinolaryngology department, were misdiagnosed, with a 12% (3/25) mortality rate. Throat discomfort can be the principal manifestation of acute coronary syndrome. Such patients exhibit high misdiagnosis and mortality rates. Exertional throat symptoms, chest tightness, perspiring, and dyspnea were important indicators of acute coronary syndrome in patients whose main complaint was throat discomfort. The awareness of this condition will result in prompt diagnosis and reduce morbidity and mortality.

关键词： acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic physicians    

HTML PDF 收藏

深碳观测计划——对地球内部碳的十年探索

Schiffries, Andrea Johnson Mangum, Jennifer L. Mays, Michelle Hoon-Starr, Robert M. Hazen

《工程（英文）》 2019年 第5卷 第3期   页码 372-378 doi: 10.1016/j.eng.2019.03.004

HTML PDF 收藏

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

null

《医学前沿（英文）》 2014年 第8卷 第4期   页码 419-426 doi: 10.1007/s11684-014-0383-6

摘要：

Aneurysmal dilatation of the aortic sinuses of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndrome. On the other hand, there is limited data in the literature about congenital sinus of Valsalva aneurysms outside this context. For the purpose of this review, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndrome, and compared this with congenital sinus of Valsalva aneurysms, also including data from a case series from our institution. In conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital sinus of Valsalva aneurysms. Though less well-recognised, congenital aneurysms are often associated with significant morbidity and mortality and timely intervention is necessary.

关键词： sinus of Valsalva aneurysms     Marfan syndrome     aortic dissection    

HTML PDF 收藏

化学工程中机器学习的优势、限制、机会和挑战 Perspective

Stevens, Kevin M. Van Geem

《工程（英文）》 2021年 第7卷 第9期   页码 1201-1211 doi: 10.1016/j.eng.2021.03.019

摘要：

化学工程师依靠模型进行工程设计、研究和日常决策制定，因为这些工作通常会伴有较大的财务和安全方面的风险。数十年来，将人工智能和化学工程进行有机结合用于建模的努力仍未满足预期效果。在过去的五年中，数据和计算资源的可获性不断提高，使基于机器学习的研究再度兴起。研究者最近努力为化学应用和新的机器学习框架开发大型数据库、基准测试集和表征，这些努力促进了机器学习技术在研究领域的推广。与传统建模技术相比，机器学习具有显著的优势，包括灵活性、精度和执行速度。但有利也有弊，比如机器学习中黑盒模型就缺乏可解释性。其最大的机遇包括在时间有限的应用场合中使用机器学习，比如需要高精度的实时优化和规划技术，并且可以建立具有自学习能力的模型去识别模式，从数据中学习，并随着时间的推移变得更加智能。然而，现在人工智能研究最大的挑战是不恰当的使用，因为大多数化学工程师只在计算机科学和数据分析方面受到有限的培训。尽管如此，机器学习肯定也会成为化学工程师建模工具箱中值得信赖的基础工具。

关键词： 人工智能     机器学习     反应工程     过程工程    

HTML PDF 收藏

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 224-228 doi: 10.1007/s11684-017-0538-3

摘要：

Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we reported six patients who underwent LTX due to BOS after HSCT (two females, four males) from January 2012 to December 2014 in our center. The median time from HSCT to diagnosis of BOS was 2.5 years (ranging from 1 to 5 years). At a median time of 4 years (ranging from 2 to 5 years) after diagnosis of BOS, four patients received bilateral sequential LTX, and two patients received single LTX. One of the recipients suffered from mild acute rejection after LTX, another suffered from primary lung graft dysfunction on post-operation day 2, and three experienced fungal infections. The median time for follow-up after LTX was 19.5 months (ranging from 12 to 39 months). At present, all patients are alive with good functional capacity and no relapse of BOS and hematologic malignancy conditions. Patients who received bilateral LTX have better pulmonary functions than patients who received single LTX.

关键词： bronchiolitis obliterans syndrome (BOS)     hematopoietic stem cell transplantation (HSCT)     lung transplantation (LTX)    

HTML PDF 收藏

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 333-339 doi: 10.1007/s11684-017-0564-1

摘要：

Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.

关键词： nephrotic syndrome     focal segmental glomerulosclerosis     genetic    

HTML PDF 收藏

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 380-383 doi: 10.1007/s11684-015-0407-x

摘要：

Cushing’s syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal complications. A case of CS during the third trimester of pregnancy secondary to adrenocortical adenoma was reported. Literature review revealed the disadvantages of different treatments in this period. Besides the conservative treatment, surgery is recommended for CS during the third trimester of pregnancy secondary to adrenal adenoma, if an experienced surgeon is available.

关键词： Cushing’s syndrome     pregnancy     adrenocortical adenoma    

HTML PDF 收藏

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

《医学前沿（英文）》 2007年 第1卷 第2期   页码 177-180 doi: 10.1007/s11684-007-0033-3

摘要： The aim of the present research is to study the mechanism of cervical nerve compression syndrome of the external intervertebral foramen and its differential diagnosis with cervical spondylosis. Diagnostic treatment with muscle relaxant, vasodilator, neurotrophic medicine and celecoxib (COX)-2 inhibitor were performed in 20 patients with cervical nerve compression syndrome of the external intervertebral foramen and 20 patients with cervical spondylosis confirmed by operation. Diagnostic local block therapy was performed additionally in cases showing little effect after diagnostic treatment. All the patients were followed up postoperatively for more than one year. Fifteen cases with cervical nerve compression syndrome of the external intervertebral foramen were healed by the diagnostic treatment. The other five cases had a short-term remission and there was no recurrence after diagnostic local block therapy. Diagnostic treatment led to short-term alleviation of the symptom in 20 cases with cervical spondylosis confirmed by operation, the results of which was far from satisfactory and operation was undertaken finally in all the 20 cases. The etiology of cervical nerve compression syndrome of the external intervertebral foramen lies in the compression of the cervical plexus, brachial plexus and cervical dorsal rami by the tendinous decussating fibers of the scalenus anticus, medius, minimus and the posterior muscles of the neck. Diagnostic treatment was propitious to differentiate cervical nerve compression syndrome of the external intervertebral foramen from cervical spondylosis.

关键词： satisfactory     COX     minimus     operation     compression syndrome    

HTML PDF 收藏

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 293-296 doi: 10.1007/s11684-017-0516-9

摘要：

Familial amyloid cardiomyopathy is a challenging condition that mimics many other diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiac abnormalities. In this case, a 57-year-old man was admitted for outpatient cardiological evaluation of progressive right heart failure and limb paraesthesias. The patient presented with hypertension, chronic Guillain-Barre syndrome, and sick sinus syndrome. Transthoracic echocardiograms showed a thickened ventricular wall and enlarged atrium. Tissue Doppler showed a restrictive filling pattern. Transthyretin (TTR)-associated amyloidosis, which was revealed by abdominal fat-pad biopsy and DNA analysis, explained the concurrence of independent pathological features, including neuropathy and cardiac involvement. Genetic testing identified a G>T mutation in exon 4 of the transthyretin (TTR) gene. This mutation resulted in the alanine-to-serine substitution at amino acid position 117. Moreover, genetic testing confirmed that the patient’s asymptomatic son carried the same amyloidogenic TTR mutation. Given these findings, the diagnosis of familial amyloid cardiomyopathy, which was misdiagnosed as chronic Guillain-Barre syndrome, was proposed.

关键词： transthyretin (TTR) cardiac amyloidosis     sick sinus syndrome     chronic Guillain-Barre syndrome    

HTML PDF 收藏

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

null

《医学前沿（英文）》 2016年 第10卷 第2期   页码 111-119 doi: 10.1007/s11684-016-0446-y

摘要：

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.

关键词： coronavirus     MERS     Middle East respiratory syndrome    

HTML PDF 收藏

Zinc homeostasis in the metabolic syndrome and diabetes

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 31-52 doi: 10.1007/s11684-013-0251-9

摘要：

Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulin storage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action. However, whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetes, or diabetic complications remains unclear. In fact, it is known that Zn deficiency is a common phenomenon in diabetic patients. Chronic low intake of Zn was associated with the increased risk of diabetes and diabetes also impairs Zn metabolism. Theoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complications; however, limited available data are not always supportive of the above notion. Therefore, this review has tried to summarize these pieces of available information, possible mechanisms by which Zn prevents the metabolic syndrome, diabetes, and diabetic complications. In the final part, what are the current issues for Zn supplementation were also discussed.

关键词： zinc     zinc transporters     metallothionein     diabetes     diabetic complications     insulin resistance     antioxidant    

HTML PDF 收藏

标题 作者 时间 类型 操作

Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

期刊论文

Ballistic behavior of plain and reinforced concrete slabs under high velocity impact

Chahmi OUCIF, Luthfi Muhammad MAULUDIN, Farid Abed

期刊论文

Imaging studies of in-cylinder HCCI combustion

Pawel LUSZCZ, Hongming XU, Mirek WYZSNSKI, Xiao MA, Rob STEVENS, Athanasios TSOLAKIS

期刊论文

Precipitation study of CO

Stevens, Guoping Hu, Wenshou Sun, Kathryn A. Mumford

期刊论文

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

期刊论文

深碳观测计划——对地球内部碳的十年探索

Schiffries, Andrea Johnson Mangum, Jennifer L. Mays, Michelle Hoon-Starr, Robert M. Hazen

期刊论文

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

null

期刊论文

化学工程中机器学习的优势、限制、机会和挑战

Stevens, Kevin M. Van Geem

期刊论文

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

null

期刊论文

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

null

期刊论文

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

null

期刊论文

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

期刊论文

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

null

期刊论文

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

null

期刊论文

Zinc homeostasis in the metabolic syndrome and diabetes

null

期刊论文